uroporphyrinogen decarboxylase การใช้

• Additionally, exposure to chlorinated cyclic hydrocarbons can lead to a deficiency in the activity of uroporphyrinogen decarboxylase, causing the buildup of excess uroporphyrinogen.
• The primary cause of this disorder is a deficiency of uroporphyrinogen decarboxylase ( UROD ), a cytosolic enzyme that is a step in the enzymatic pathway that leads to the synthesis of heme.
• The combination of this increased demand and reduced activity of uroporphyrinogen decarboxylase disrupts heme production and allows byproducts of the process to accumulate in the body, triggering the signs and symptoms of porphyria cutanea tarda.